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INDICATIONS AND USAGE CLOMID
Is indicated for the treatment of ovulatory dysfunction in women desiring
pregnancy. Impediments to achieving pregnancy must be excluded or adequately
treated before beginning CLOMID therapy. Those patients most likely to achieve
success with clomiphene therapy include patients with polycystic ovary syndrome
(see WARNINGS : Ovarian Hyperstimulation Syndrome ), amenorrhea-galactorrhea
syndrome, psychogenic amenorrhea, post-oral-contraceptive amenorrhea, and
certain cases of secondary amenorrhea of undetermined etiology. Properly
timed coitus in relationship to ovulation is important. A basal body temperature
graph or other appropriate tests may help the patient and her physician
determine if ovulation occurred. Once ovulation has been established, each
course of CLOMID should be started on or about the 5th day of the cycle.
Long-term cyclic therapy is not recommended beyond a total of about six
cycles (including three ovulatory cycles). See DOSAGE AND ADMINISTRATION
and PRECAUTIONS . ) CLOMID is indicated only in patients with demonstrated
ovulatory dysfunction who meet the conditions described below (see CONTRAINDICATIONS
): Patients who are not pregnant. Patients without ovarian cysts. CLOMID
should not be used in patients with ovarian enlargement except those with
polycystic ovary syndrome. Pelvic examination is necessary prior to the
first and each subsequent course of CLOMID treatment. Patients without abnormal
vaginal bleeding. If abnormal vaginal bleeding is present, the patient should
be carefully evaluated to ensure that neoplastic lesions are not present.
Patients with normal liver function. In addition, patients selected for
CLOMID therapy should be evaluated in regard to the following: Estrogen
Levels. Patients should have adequate levels of endogenous estrogen (as
estimated from vaginal smears, endometrial biopsy, assay of urinary estrogen,
or from bleeding in response to progesterone). |
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